The Virginia Tech Hokies will travel to Louisville, Kentucky to face the 13^th-ranked Louisville Cardinals at L&N Federal Credit Union Stadium in a battle between two ACC teams in week 10 of the college football season with the game kicking off at 3:30 PM ET and airing on the ACC Network on Saturday afternoon.

Virginia Tech enters this game with a record of 4-4 and is on a two-game winning streak following a 38-10 win at home against the Syracuse Orange while covering the 2.5-point spread as a home favorite in week 9 of the college football season. The Hokies scored 38 points while compiling a total of 528 yards offensively which included 210 passing yards and 318 rushing yards while allowing 10 points and 138 total yards defensively which included 138 passing yards and 0 rushing yards. 

Kyron Drones led the team in passing, completing 15 of 24 attempts for 194 yards and a touchdown while rushing for 56 yards on eight attempts. Bhayshul Tuten led the team in rushing with 18 carries for 118 yards and a touchdown while adding a reception for 11 yards. Da’Quan Felton led the team in receiving, catching three of eight targets for 80 yards and two touchdowns.

The Louisville Cardinals enter this game ranked 13^th in the College Football Playoff rankings with a record of 7-1 following a 23-0 win at home against the Duke Blue Devils while covering the 5-point spread as a home favorite in week 9 of the college football season. Louisville scored 23 points while compiling a total of 351 yards offensively which included 117 passing yards and 234 rushing yards while shutting out Duke and allowing 202 total yards defensively which included 151 passing yards and 51 rushing yards. 

Jack Plummer led the team in passing, completing 11 of 16 attempts for 117 yards. Jawhar Jordan led the team in rushing with 21 carries for 163 yards and two touchdowns. Jamari Thrash led the team in receiving, catching seven of nine targets for 73 yards.

BookMaker has the Louisville Cardinals listed as 9.5-point favorites at home against the Virginia Tech Hokies on Saturday afternoon in week 10 of the college football season. Virginia Tech has won both games in the series while winning by an average margin of 9 points per game in those matchups and going 2-0 ATS all-time in the series. The Virginia Tech Hokies are 5-3 ATS overall, 1-2 ATS on the road, 2-2 ATS as an underdog, and 4-0 ATS in conference games this season while the Louisville Cardinals are 4-4 ATS overall, 4-0 ATS at home, 3-4 ATS as a favorite, and 2-3 ATS in conference games on the year.

Louisville is the more talented team, however, Virginia Tech has been the better team in the series, winning both games all-time and going 2-0 ATS in those contests. The Cardinals have covered the spread in their conference games going 4-0 ATS in conference play while the Hokies have a losing record at covering the spread going 2-3 ATS in conference games this season. Buy the .5 point and take the points with the Virginia Tech Hokies when they travel to face the Louisville Cardinals.