The Notre Dame Fighting Irish have had arguably the toughest three-game stretch this season in college football having faced the undefeated Ohio State Buckeyes, then the undefeated Duke Blue Devils, and now have to travel to take on the undefeated Louisville Cardinals on Saturday evening at L&N Federal Credit Union Stadium in Louisville, Kentucky. Will the Cardinals remain undefeated or will the Fighting Irish get the win on the road? Let’s take a look at how these teams have fared this season. 

The Notre Dame Fighting Irish enter this game ranked 10^th in the AP Poll and 11^th in the Coaches Poll with a record of 5-1 following a 21-14 win on the road against the Duke Blue Devils while covering the 5.5-point spread as a road favorite in week 5 of the college football season. Notre Dame scored 21 points while compiling a total of 381 yards offensively which included 222 passing yards and 159 rushing yards while allowing 14 points and 323 total yards offensively which included 134 passing yards and 189 rushing yards. Sam Hartman led the team in passing, completing 15 of 30 attempts for 222 yards while rushing for 23 yards. Audric Estime led the team in rushing with 18 carries for 81 yards and two touchdowns while adding four receptions for 25 yards. Mitchell Evans led the team in receiving, catching six of eight targets for 134 yards.

Louisville enters this game ranked 25^th in the AP Poll and 25^th in the Coaches Poll with a record of 5-0 following a 13-10 win on the road against the NC State Wolfpack while failing to cover the 3.5-point spread as a road favorite in week 5 of the college football season. The Cardinals scored 13 points while compiling a total of 306 yards offensively which included 286 passing yards and 20 rushing yards while allowing 10 points and 201 total yards defensively which included 112 passing yards and 89 rushing yards. Jack Plummer led the team in passing, completing 21 of 35 attempts for 286 yards with a touchdown and two interceptions. Jawhar Jordan led the team in rushing with 16 carries for 32 yards while adding a reception for 26 yards. Chris Bell led the team in receiving, catching three of four targets for 85 yards and a touchdown. 

BookMaker has the Notre Dame Fighting Irish listed as 6.5-point favorites on the road against the Louisville Cardinals on Saturday evening in week 6 of the college football season. Notre Dame has won two of the three games all-time in the series while Louisville is 3-0 ATS in those matchups. The Fighting Irish are 4-1-1 ATS overall, 2-0 ATS on the road, and 4-1 ATS as a favorite this season while the Louisville Cardinals are 2-3 ATS overall and 2-0 ATS at home on the year. 

Notre Dame is the higher-ranked team entering this matchup and has been the better team in the series, winning two of the three games all-time. However, the Cardinals have been the better team at covering the spread going 3-0 ATS all-time in the series. As a result, I am buying the .5 point and taking the Louisville Cardinals +7 on BookMaker for this matchup on Saturday evening.