The USC Trojans are one of the best teams in college football this season while the Colorado Buffaloes showed just how much they have to improve on both sides of the ball after a blowout loss against the Oregon Ducks in week 4 of the college football season. Will the Trojans improve to 5-0 in a rout or will the Buffaloes keep the game closer than expected? Let’s take a look at how these teams have fared this season.

The USC Trojans enter this game ranked 8^th in the AP Poll and 6^th in the Coaches Poll with a record of 4-0 following a 42-28 win on the road against the Arizona State Sun Devils while failing to cover the 34.5-point spread as a road favorite in week 4 of the college football season. USC scored 42 points while compiling a total of 535 total yards offensively which included 322 passing yards and 213 rushing yards while allowing 28 points while allowing 353 total yards defensively which included 263 passing yards and 90 rushing yards. Caleb Williams led the team in passing, completing 20 of 31 attempts for 322 yards and three touchdowns while rushing for 10 yards and two touchdowns. MarShawn Lloyd led the team in rushing with 14 carries for 154 yards. Brenden Rice led the team in receiving, catching seven of nine targets for 133 yards and two touchdowns.

Colorado enters this game with a record of 3-1 following a 6-42 loss on the road against the Oregon Ducks while failing to cover the 21-point spread as a road underdog in week 4 of the college football season. The Buffaloes scored 6 points while compiling a total of 199 yards offensively which included 159 passing yards and 40 rushing yards while allowing 42 points and 522 total yards defensively which included 282 passing yards and 240 rushing yards. Shedeur Sanders led the team in passing, completing 23 of 33 attempts for 159 yards and a touchdown. Anthony Hankerson led the team in rushing with five carries for 31 yards. Xavier Weaver led the team in receiving, catching nine of 13 targets for 75 yards.

BookMaker has the USC Trojans listed as 21-point favorites on the road against the Colorado Buffaloes on Saturday afternoon in week 5 of the college football season. USC has won the last ten games in the series while going 6-4 ATS in the last ten and 2-1 ATS in the last three matchups. USC is 2-2 ATS overall, 0-1 ATS on the road, 2-2 ATS as a favorite, and 1-1 ATS in conference games this season while the Colorado Buffaloes are 2-2 ATS overall, 1-1 ATS at home, 1-1 ATS as an underdog, and 0-1 ATS in conference games this season.

USC is the more talented team and has been the dominant team in the series, winning the last ten games in a row. The Trojans are 6-4 ATS in the last ten and 2-1 ATS in the last three games in the series. As a result, I am taking the USC Trojans -21 on BookMaker for this matchup in week 5 of the college football season.