In a battle between two AFC South rivals the Indianapolis Colts will take to Jacksonville, Florida to face the Jacksonville Jaguars at EverBank Stadium which will air on CBS at 1:00 PM ET on Sunday afternoon in week 6 of the NFL season.

The Indianapolis Colts enter this game with a record of 3-2 following a 23-16 win at home against the Tennessee Titans while covering the 2.5-point spread as a home underdog in week 5 of the NFL season. Indianapolis scored 23 points while compiling a total of 429 yards offensively which included 253 passing yards and 193 rushing yards while allowing 16 points and 348 total yards defensively which included 264 passing yards and 89 rushing yards. Gardner Minshew led the team in passing, completing 11 of 14 attempts for 155 yards. Zack Moss led the team in rushing with 23 carries for 165 yards and two touchdowns while adding two receptions for 30 yards. Josh Downs led the team in receiving, catching all six targets for 97 yards.

Jacksonville enters this game with a record of 3-2 following a 25-20 win in London against the Buffalo Bills while covering the 5-point spread as an underdog in week 5 of the NFL season. The Jaguars scored 25 points while compiling a total of 474 total yards offensively which included 315 passing yards and 196 rushing yards while allowing 20 points and 388 total yards defensively which included 359 passing yards and 29 rushing yards. Trevor Lawrence led the team in passing, completing 25 of 37 attempts for 315 yards and a touchdown while adding 31 rushing yards. Travis Etienne led the team in rushing with 26 carries for 136 yards and two touchdowns while adding four receptions for 48 yards. Calvin Ridley led the team in receiving, catching seven of eight targets for 122 yards.

BookMaker has the Jacksonville Jaguars listed as 4-point favorites at home against the Indianapolis Colts on Sunday afternoon in week 6 of the NFL season. Jacksonville has won six of the last ten and two of the last three matchups while going 8-2 ATS in the last ten and 2-1 ATS in the last three games in the series. Indianapolis is 3-2 ATS overall, 2-0 ATS on the road, 3-2 ATS as an underdog, and 2-1 ATS in division games this season while the Jacksonville Jaguars are 3-2 ATS overall, 0-2 ATS at home, 2-1 ATS as a favorite, and 1-1 ATS in division games on the year.

Jacksonville will be back in the United States following two games in London and will be facing a team they have fared well against the Indianapolis Colts winning six of the last ten and two of the last three games while also being the better team at covering the spread going 8-2 ATS in the last ten and 2-1 ATS in the last three games. The winner of this game will take sole possession of 1^st place in the AFC South and I look for the team that was the favorite to win the division before the season to take control on Sunday which is why I am taking the Jacksonville Jaguars -4 at home against the Indianapolis Colts.