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NFL Betting Preview: Jacksonville Jaguars vs. San Francisco 49ers

November 12, 2023

The San Francisco 49ers will travel to Jacksonville, Florida to face the Jacksonville Jaguars at EverBank Stadium in week 10 of the NFL season with the game scheduled to start at 1:00 PM ET on Sunday afternoon and will air regionally on Fox.

San Francisco was looking like one of the best teams in the NFC following a 42-10 win at home against the Dallas Cowboys in week 5 which improved their record to 5-0, however, since that game the 49ers have lost three straight games including a 17-31 loss at home against the Cincinnati Bengals while failing to cover the 4.5-point spread as a home favorite in week 8. The offense has been one of the reasons that the San Francisco 49ers have struggled over their last three games as they went from averaging 33.4 points per game in the first five games of the season to averaging 17 points per game over their losing streak. The defense still remains one of the best defenses in the NFL as they rank 4th in the NFL allowing an average of 17.5 points per game.

The Jacksonville Jaguars have been one of the hottest teams over the last few weeks as they enter this game on a five-game winning streak which includes a 20-10 win on the road against the Pittsburgh Steelers in week 8 to improve their record to 6-2 on the year which puts them in 1st place in the AFC South. At the beginning of the season, the Jaguars looked lost as they started 1-2 in their first three games and were averaging 19 points per game, however, over their last five games they have averaged 27.2 points per game and now rank 10th in the NFL in points per game with an average of 24.13 points per game. However, they will be facing one of the best scoring defenses in the NFL in week 10 when they host the San Francisco 49ers.

BookMaker has the San Francisco 49ers listed as 3-point favorites on the road against the Jacksonville Jaguars on Sunday afternoon in week 10 of the NFL season. San Francisco has won four of the six games all-time including the previous four meetings in a row while going 5-1 ATS all-time and covering the spread in the last five games in the series. The San Francisco 49ers are 4-4 ATS overall, 1-3 ATS on the road, and 4-4 ATS as a favorite this season while the Jacksonville Jaguars are 6-2 ATS overall, 1-2 ATS at home, and 2-1 ATS as an underdog on the year.

Jacksonville enters this game on a five-game winning streak while San Francisco has lost three games in a row. The Jaguars have also been one of the best teams in the NFL at covering the spread this season going 6-2 ATS overall and are 2-1 ATS as an underdog while the 49ers are 4-4 ATS overall and 4-4 ATS as a favorite and have not covered the spread since week 5 at home against the Cowboys. Take the points with the Jacksonville Jaguars when they host the San Francisco 49ers in week 10. 

Spooky Express Pick: Jacksonville Jaguars +3