The triple-header on Thanksgiving will conclude on Thanksgiving night when the San Francisco 49ers travel to Seattle, Washington to face the Seattle Seahawks at Lumen Field in a battle of two NFC West division rivals with the game kicking off at 8:20 PM ET and will air on NBC and the Peacock app.

Following their bye week, the San Francisco 49ers have gone on a two-game winning streak with wins on the road against the Jacksonville Jaguars by a score of 34-3 and at home against the Tampa Bay Buccaneers by a score of 27-14. The defense has played well over the last two games as to be expected, however, Brock Purdy has looked like one of the best quarterbacks in the league during the winning streak as he has completed 40 of 51 passes for 629 yards with six touchdowns and no interceptions during the streak. The 49ers are in 1^st place in the NFC West with a record of 7-3 following the win against the Tampa Bay Buccaneers and will be looking to extend their winning streak to three games when they face the Seattle Seahawks in week 12 of the NFL season.

There is a possibility that Geno Smith doesn’t play in this matchup even though he came back in to finish the game in their loss against the Los Angeles Rams on Sunday after exiting the game with an elbow injury. The Seahawks are currently in 2^nd place in the NFC West with a record of 6-4, however, they are coming off a 16-17 loss on the road against the Los Angeles Rams in which they led 16-7 going into the 4^th quarter before allowing the Rams to score 10 unanswered points. The offense has been slightly above average this season as they enter this game averaging 22.22 points per game which is above the league average of 21.8 points per game, however, they will be facing a defense that has only allowed an average of 8.5 points per game over their last three games when they host the San Francisco 49ers on Thanksgiving night.

BookMaker has the San Francisco 49ers listed as 7-point favorites on the road against the Seattle Seahawks on Thanksgiving night in week 12 of the NFL season. The teams are 5-5 in the last ten meetings while San Francisco has won the last three matchups while going 6-4 ATS in the last ten and 3-0 ATS in the last three games in the series. The San Francisco 49ers are 5-5 ATS overall, 2-3 ATS on the road, 5-5 ATS as a favorite, and 1-1 ATS in division games this season while the Seattle Seahawks are 5-4-1 ATS overall, 2-2-1 ATS at home, 2-2 ATS as an underdog, and 2-1 ATS in division games on the year.

San Francisco has been one of the best teams in the NFL this season and has the best scoring defense in the league. The Seahawks may not have their starting quarterback, Geno Smith, for this game which doesn’t bode well for a team that is only slightly above average as a scoring team this season and has lost three straight against the 49ers. San Francisco has covered the last three meetings against Seattle and I look for them to make it four straight on Thanksgiving night.