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San Francisco 49ers vs. LA Rams

September 22, 2024


Written By: Evan Perkins

The San Francisco 49ers (1-1) and Los Angeles Rams (0-2) will battle on Sunday, September 22 at 4:25 PM ET at SoFi Stadium in Inglewood, California. In this NFL betting opportunity, the 49ers are favorites with a point spread at -7.0 (-115).


San Francisco 49ers Betting Preview


The 49ers stumbled in their last matchup, a 23-17 loss against the Minnesota Vikings. The offense had some issues, as they did not make an impactful run until late in the fourth quarter.


Brock Purdy had a solid performance, completing 28 of his 36 passes for 319 yards. He scored a touchdown but also recorded an interception. If they had kept the turnovers down, they would have arguably won this game.


The 49ers had more first downs and similar yardage compared to the Vikings. Both teams had two turnovers, but it felt as if the momentum was shifting late for the 49ers. Again, turnovers are killer for many teams.


They have accumulated 49 points in two games, which averages 24.5 points per game and ranks ninth in the league. On defense, they have allowed 42 total points, averaging 21.0 points a game and racing 15th.


Los Angeles Rams Betting Preview


The Rams suffered an ugly 41-10 defeat against the Arizona Cardinals, marking their second consecutive loss to start the season. They were down 24-3 going into the half, and not much offense came their way in the second half either, as the Cardinals rolled on.


Matthew Stafford performed well when the team needed him to do more. He completed 19 of his 27 passes for 216 yards. While many teams in the league would have loved to have a quarterback like this each night, the Rams need him to be spectacular in similar battles.


The Rams had the ball for about 23 minutes, during which time they gained 245 yards and 14 first downs. Defensively, they allowed the Cardinals to gain 489 yards and 24 first downs.


Their offense has scored 30 points, which averages 15.0 a game and ranks 27th. Their defense has allowed 67 points, translating to 33.5 a game and ranking second to last (31st).


Odds, Series Trends, and Free Pick


MyBookie showcases the best NFL betting odds in the San Francisco 49ers vs. Los Angeles Rams showdown. The 49ers are currently seven-point favorites, and market insights suggest they have a 63.9 percent chance of winning.


The offense from the 49ers is more appealing on paper to get the job done. Star wide receiver Cooper Kupp is doubtful for the Rams, which is another reason they will likely struggle in this game. Look for the 49ers to cover the spread.


Final Pick: San Francisco 49ers -7.0 (-115)